Three educators, four lecture series, ~10 hours of clinical material. Each module builds on the last.
Reed & Dickerson on CYP450 metabolism, ion-channel gates (ANK3, CACNA1C), pharmacodynamic genes (HTR2A, SLC6A4, COMT, BDNF, ADRA2A, DRD2, OPRM1), and HLA-mediated SJS risk.
Hausman-Cohen on the IntellxxDNA framework — moving beyond drug metabolism to the underlying biological drivers (HTR1A, NPSR1, DIO2, ESR2, BDNF, MTHFD1L, F2, GCH1, and dozens more).
Kraker on the CNR1 tri-loop pathway, kynurenine shunt of inflammation, NF-κB master switch, and the ‘Catherine’ case — 41 yo with 25 years of partial responders, 53 lbs lost, recovered.
When a PGx report comes back, search the gene symbol in the bar above (or press /). Each gene page lists alleles, phenotype frequencies, and evidence-based interventions — both pharmacologic and nutraceutical.
Open Gene Atlas →Walk through the visualized pathways — methylation, neurotransmitter synthesis, the CNR1 tri-loop, the inflammation→brain pipeline. Each diagram links to the genes that matter at every step.
View Pathways →The Quick Reference page gives printable gene-cards and ‘refrigerator versions’ of supplement protocols organized by phenotype.
Print References →All ten lecture transcripts and slide decks are searchable in the Lecture Library — every quote, every dose, every case.
Open Library →Pharmacogenomics tells you which drug to use. Root-cause genomics asks why this person is depressed — is it serotonin synthesis (TPH/BH4)? Methylation (MTHFR/MTRR)? Inflammation (IL-6/TNF-α)? Estrogen (ESR2)? Endocannabinoid (CNR1)?
Pharmacogenomics alone gets ~20% of treatment-resistant patients to remission. Root cause genomics targets the other 80%.
Sodium fires (ANK3) → calcium opens (CACNA1C) → all neurotransmitters release. Disrupted gates = mood instability. Lithium is the only common drug that works on both gates. Stabilize gates → then add antidepressant or methylfolate.
‘Lithium is the cake. Everything else is the icing.’ — Reed
Methylfolate ≠ folic acid (and not everyone needs methylfolate — some need folinic). P5P ≠ pyridoxine (the latter is neurotoxic in carriers). Methyl- + adenosyl-cobalamin ≠ cyanocobalamin. Magnesium L-threonate ≠ other magnesiums for brain effects.
Before remodeling — address the fundamentals: inflammation, oxidative stress, gut, nutrients. Magnesium, B12, folate, zinc, vitamin C and D, and gluten removal (when HLA-DQ2.5 +) often produce dramatic gains before any neurotransmitter intervention.