:root { --radius: 14px; --mono: ui-monospace, "JetBrains Mono", "SF Mono", Menlo, monospace; --serif: "Iowan Old Style", "Apple Garamond", Georgia, serif; /* Default to dark; data-theme on overrides */ --bg: #0b1020; --bg-2: #11172d; --panel: #161e3b; --panel-2: #1d264a; --border: #2a3460; --ink: #e6ecff; --ink-dim: #aeb6d4; --ink-faint: #7884a8; --accent: #6cd4ff; --accent-2: #ff6cb1; --accent-3: #ffd166; --good: #6dd896; --warn: #ffb86b; --bad: #ff7b8b; --gradient: linear-gradient(135deg, #6cd4ff 0%, #ff6cb1 100%); --shadow-1: 0 4px 14px rgba(0,0,0,.25); --shadow-2: 0 10px 32px rgba(0,0,0,.4); /* Brand colors stay for the gradient hero */ --brand-cyan: #6cd4ff; --brand-pink: #ff6cb1; --brand-amber: #ffd166; } html[data-theme="dark"] { color-scheme: dark; } html[data-theme="light"] { color-scheme: light; --bg: #f6f7fb; --bg-2: #ffffff; --panel: #ffffff; --panel-2: #eef1fb; --border: #d6dbef; --ink: #0f1535; --ink-dim: #475371; --ink-faint: #7c87a3; /* Deeper accents that read well on white */ --accent: #0e7490; /* cyan-700 */ --accent-2: #be185d; /* pink-700 */ --accent-3: #b45309; /* amber-700 */ --good: #15803d; /* emerald-700 */ --warn: #c2410c; /* orange-700 */ --bad: #be123c; /* rose-700 */ --gradient: linear-gradient(135deg, #0e7490 0%, #be185d 100%); --shadow-1: 0 2px 8px rgba(15,21,53,.07); --shadow-2: 0 8px 24px rgba(15,21,53,.10); } /* Visualizations always stay dark — the SVG fills are tuned for dark backgrounds. */ html[data-theme="light"] .viz-frame { background: #11172d; border-color: #2a3460; color: #e6ecff; } html[data-theme="light"] .viz-counter { background: #161e3b; border-color: #2a3460; } html[data-theme="light"] .viz-counter .label { color: #7884a8; } html[data-theme="light"] .viz-counter .value { color: #ff7b8b; } html[data-theme="light"] .viz-counter .value.calm { color: #6dd896; } html[data-theme="light"] .viz-controls label { background: #161e3b; border-color: #2a3460; color: #aeb6d4; } html[data-theme="light"] .viz-controls label.active { background: #6cd4ff; color: #0b1020; border-color: #6cd4ff; } html[data-theme="light"] .viz-controls .legend { color: #7884a8; } html[data-theme="light"] .viz-controls input[type="checkbox"] { accent-color: #6cd4ff; } /* Hero gradient overlay — softer in light mode */ html[data-theme="light"] .hero::before { background: radial-gradient(800px 300px at 30% 10%, rgba(14,116,144,.08) 0, transparent 60%), radial-gradient(700px 280px at 80% 0%, rgba(190,24,93,.06) 0, transparent 60%); } html[data-theme="light"] #heroDna { opacity: .25; } * { box-sizing: border-box; } html, body { margin: 0; padding: 0; } body { font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, "Helvetica Neue", Arial, sans-serif; background: var(--bg); color: var(--ink); line-height: 1.55; -webkit-font-smoothing: antialiased; } a { color: var(--accent); text-decoration: none; } a:hover { text-decoration: underline; } /* ============= TOPBAR ============= */ .topbar { position: sticky; top: 0; z-index: 50; background: rgba(11,16,32,.85); backdrop-filter: saturate(160%) blur(12px); -webkit-backdrop-filter: saturate(160%) blur(12px); border-bottom: 1px solid var(--border); } html[data-theme="light"] .topbar { background: rgba(255,255,255,.9); } /* Theme toggle */ .theme-toggle { display: inline-flex; align-items: center; justify-content: center; width: 36px; height: 36px; border-radius: 10px; background: var(--panel); border: 1px solid var(--border); color: var(--ink-dim); cursor: pointer; font-size: 16px; line-height: 1; transition: background .15s, color .15s, transform .15s; user-select: none; } .theme-toggle:hover { color: var(--ink); background: var(--panel-2); } .theme-toggle:active { transform: scale(.94); } .topbar-inner { max-width: 1280px; margin: 0 auto; padding: 14px 24px; display: flex; align-items: center; gap: 24px; } .brand { display: flex; align-items: baseline; gap: 10px; font-weight: 700; font-size: 18px; color: var(--ink); } .brand .mark { display: inline-block; width: 14px; height: 14px; border-radius: 4px; background: var(--gradient); } .brand .sub { font-weight: 400; font-size: 13px; color: var(--ink-faint); } .nav { display: flex; gap: 4px; flex: 1; flex-wrap: wrap; } .nav a { color: var(--ink-dim); padding: 8px 12px; border-radius: 8px; font-size: 14px; font-weight: 500; } .nav a:hover { color: var(--ink); background: var(--panel-2); text-decoration: none; } .nav a.active { color: var(--ink); background: var(--panel-2); } .search-box { position: relative; } .search-box input { background: var(--panel); border: 1px solid var(--border); color: var(--ink); border-radius: 10px; padding: 8px 12px 8px 32px; width: 260px; font-size: 13px; outline: none; } .search-box input:focus { border-color: var(--accent); } .search-box .icon { position: absolute; left: 10px; top: 9px; color: var(--ink-faint); } .search-results { position: absolute; right: 0; top: 100%; margin-top: 6px; width: 380px; max-height: 480px; overflow-y: auto; background: var(--panel); border: 1px solid var(--border); border-radius: 10px; padding: 6px; display: none; z-index: 60; box-shadow: var(--shadow-2); } .search-results.active { display: block; } .search-results .result { padding: 8px 10px; border-radius: 6px; cursor: pointer; display: block; color: var(--ink); } .search-results .result:hover { background: var(--panel-2); text-decoration: none; } .search-results .result .label { font-size: 11px; color: var(--accent); text-transform: uppercase; letter-spacing: .05em; } .search-results .result .title { font-weight: 600; font-size: 14px; margin-top: 2px; } .search-results .result .snippet { font-size: 12px; color: var(--ink-dim); margin-top: 3px; } /* ============= LAYOUT ============= */ .container { max-width: 1280px; margin: 0 auto; padding: 32px 24px 80px; } .container.narrow { max-width: 880px; } h1 { font-size: 32px; line-height: 1.15; font-weight: 700; margin: 0 0 12px; letter-spacing: -.02em; } h2 { font-size: 22px; line-height: 1.25; font-weight: 700; margin: 32px 0 14px; } h3 { font-size: 17px; line-height: 1.3; font-weight: 600; margin: 22px 0 10px; } .subtitle { color: var(--ink-dim); font-size: 16px; margin: 0 0 24px; max-width: 700px; } .grid { display: grid; gap: 20px; } .grid.cols-2 { grid-template-columns: repeat(auto-fit, minmax(360px, 1fr)); } .grid.cols-3 { grid-template-columns: repeat(auto-fit, minmax(280px, 1fr)); } .grid.cols-4 { grid-template-columns: repeat(auto-fit, minmax(220px, 1fr)); } .card { background: var(--panel); border: 1px solid var(--border); border-radius: var(--radius); padding: 20px; } .card.hover { transition: transform .15s, border-color .15s; cursor: pointer; } .card.hover:hover { transform: translateY(-2px); border-color: var(--accent); } .kbd { font-family: var(--mono); font-size: 12px; background: var(--panel-2); border: 1px solid var(--border); border-radius: 4px; padding: 2px 6px; } .tag { display: inline-block; font-size: 11px; padding: 3px 10px; border-radius: 999px; font-weight: 600; background: var(--panel-2); color: var(--ink-dim); border: 1px solid var(--border); margin: 2px 4px 2px 0; } .tag.pharmacokinetic { background: rgba(239,68,68,.15); color: #ff7b8b; border-color: rgba(239,68,68,.3); } .tag.electrolyte-gate { background: rgba(108,212,255,.15); color: var(--accent); border-color: rgba(108,212,255,.3); } .tag.neurotransmitter-builder { background: rgba(255,209,102,.15); color: var(--accent-3); border-color: rgba(255,209,102,.3); } .tag.antidepressant-response { background: rgba(255,108,177,.15); color: var(--accent-2); border-color: rgba(255,108,177,.3); } .tag.executive-function { background: rgba(109,216,150,.15); color: var(--good); border-color: rgba(109,216,150,.3); } .tag.addiction { background: rgba(255,184,107,.15); color: var(--warn); border-color: rgba(255,184,107,.3); } .tag.arousal-anxiety { background: rgba(168,108,255,.15); color: #a86cff; border-color: rgba(168,108,255,.3); } .tag.hormonal { background: rgba(255,108,177,.15); color: var(--accent-2); border-color: rgba(255,108,177,.3); } .tag.vascular { background: rgba(255,123,139,.15); color: #ff7b8b; border-color: rgba(255,123,139,.3); } .tag.gut-detox { background: rgba(255,184,107,.15); color: var(--warn); border-color: rgba(255,184,107,.3); } .tag.nutrient { background: rgba(255,209,102,.15); color: var(--accent-3); border-color: rgba(255,209,102,.3); } .tag.antioxidant { background: rgba(109,216,150,.15); color: var(--good); border-color: rgba(109,216,150,.3); } .tag.immune { background: rgba(168,108,255,.15); color: #a86cff; border-color: rgba(168,108,255,.3); } .tag.inflammation { background: rgba(239,68,68,.15); color: #ff7b8b; border-color: rgba(239,68,68,.3); } .tag.endocannabinoid { background: rgba(108,212,255,.15); color: var(--accent); border-color: rgba(108,212,255,.3); } .tag.transporter { background: rgba(168,108,255,.15); color: #a86cff; border-color: rgba(168,108,255,.3); } /* ============= HERO ============= */ .hero { position: relative; padding: 64px 0 48px; border-bottom: 1px solid var(--border); margin-bottom: 32px; overflow: hidden; } .hero::before { content: ""; position: absolute; inset: 0; background: radial-gradient(800px 300px at 30% 10%, rgba(108,212,255,.15) 0, transparent 60%), radial-gradient(700px 280px at 80% 0%, rgba(255,108,177,.12) 0, transparent 60%); z-index: -1; } .hero h1 { font-size: 44px; line-height: 1.1; max-width: 800px; } .hero .subtitle { font-size: 18px; max-width: 660px; } /* ============= TABLES ============= */ table.data { width: 100%; border-collapse: collapse; font-size: 14px; background: var(--panel); border-radius: var(--radius); overflow: hidden; border: 1px solid var(--border); } table.data th, table.data td { text-align: left; padding: 12px 14px; border-bottom: 1px solid var(--border); vertical-align: top; } table.data thead th { background: var(--panel-2); font-size: 12px; text-transform: uppercase; letter-spacing: .05em; color: var(--ink-dim); font-weight: 600; } table.data tbody tr:last-child td { border-bottom: none; } table.data tbody tr:hover { background: var(--panel-2); } /* ============= PILL FILTER ============= */ .pill-filter { display: flex; flex-wrap: wrap; gap: 6px; margin-bottom: 18px; } .pill { padding: 6px 12px; border-radius: 999px; background: var(--panel); border: 1px solid var(--border); color: var(--ink-dim); font-size: 13px; cursor: pointer; user-select: none; } .pill:hover { background: var(--panel-2); color: var(--ink); } .pill.active { background: var(--ink); color: var(--bg); border-color: var(--ink); } /* ============= GENE CARD ============= */ .gene-card { background: var(--panel); border: 1px solid var(--border); border-radius: var(--radius); padding: 20px; transition: border-color .15s; } .gene-card:hover { border-color: var(--accent); } .gene-card .symbol { font-family: var(--mono); font-size: 22px; font-weight: 700; background: var(--gradient); -webkit-background-clip: text; background-clip: text; color: transparent; } .gene-card .full-name { font-size: 12px; color: var(--ink-dim); margin-top: -4px; } .gene-card .function { font-size: 14px; color: var(--ink-dim); margin: 12px 0 8px; } .gene-card .alleles { margin-top: 8px; } .gene-card .allele { font-size: 13px; padding: 8px 0; border-top: 1px dashed var(--border); } .gene-card .allele:first-child { border-top: none; } .gene-card .allele .name { font-family: var(--mono); font-weight: 700; color: var(--ink); } .gene-card .allele .effect { color: var(--ink-dim); display: block; margin-top: 2px; } .gene-card details { margin-top: 12px; } .gene-card summary { cursor: pointer; font-size: 13px; color: var(--accent); padding: 4px 0; user-select: none; } .gene-card .interventions { margin-top: 8px; padding-left: 18px; font-size: 13px; color: var(--ink-dim); } .gene-card .interventions li { margin: 4px 0; } .gene-card .clinical-notes { margin-top: 8px; font-size: 13px; color: var(--ink-dim); padding: 10px; background: var(--panel-2); border-radius: 8px; border-left: 3px solid var(--accent-3); } /* ============= CASE CARD ============= */ .case-card { background: var(--panel); border: 1px solid var(--border); border-radius: var(--radius); padding: 24px; } .case-card .title-row { display: flex; align-items: baseline; justify-content: space-between; flex-wrap: wrap; gap: 12px; } .case-card .title-row h3 { margin: 0; font-size: 20px; } .case-card .meta { color: var(--ink-faint); font-size: 12px; } .case-card .summary { font-style: italic; color: var(--ink-dim); margin: 8px 0 14px; } .case-card section { margin: 18px 0; } .case-card h4 { font-size: 13px; text-transform: uppercase; color: var(--ink-faint); letter-spacing: .07em; margin: 0 0 8px; font-weight: 600; } .case-card ul { padding-left: 18px; margin: 0; font-size: 14px; color: var(--ink-dim); } .case-card ul li { margin: 4px 0; } .case-card .snp-row { display: flex; align-items: baseline; gap: 8px; padding: 6px 0; border-bottom: 1px dashed var(--border); } .case-card .snp-row:last-child { border-bottom: none; } .case-card .snp-row .gene { font-family: var(--mono); font-weight: 700; color: var(--ink); min-width: 130px; } .case-card .snp-row .note { color: var(--ink-dim); font-size: 13px; } .case-card .plan-row { padding: 6px 0; border-bottom: 1px dashed var(--border); } .case-card .plan-row:last-child { border-bottom: none; } .case-card .plan-row .intervention { font-weight: 600; color: var(--ink); font-size: 14px; } .case-card .plan-row .dose { color: var(--accent); font-size: 12px; font-family: var(--mono); margin-left: 8px; } .case-card .plan-row .rationale { color: var(--ink-dim); font-size: 13px; margin-top: 2px; } .case-card .outcome { background: linear-gradient(135deg, rgba(109,216,150,.1), rgba(108,212,255,.1)); border: 1px solid rgba(109,216,150,.3); border-left: 3px solid var(--good); padding: 14px 16px; border-radius: 8px; font-size: 14px; } /* ============= PATHWAY VIZ ============= */ .pathway-svg { width: 100%; height: auto; background: var(--bg-2); border-radius: var(--radius); border: 1px solid var(--border); } .pathway-node rect, .pathway-node circle { stroke: var(--border); } .pathway-node text { font-size: 11px; fill: var(--ink); font-family: -apple-system, sans-serif; } .pathway-edge { stroke: var(--ink-faint); fill: none; } .pathway-edge-label { font-size: 10px; fill: var(--accent); font-family: var(--mono); } /* ============= BIG NUMBER STAT ============= */ .stat { padding: 18px; background: var(--panel); border: 1px solid var(--border); border-radius: var(--radius); } .stat .value { font-size: 28px; font-weight: 700; background: var(--gradient); -webkit-background-clip: text; background-clip: text; color: transparent; } .stat .label { font-size: 13px; color: var(--ink-dim); margin-top: 4px; } /* ============= CYP CHART ============= */ .cyp-bar { display: flex; align-items: center; gap: 10px; margin: 8px 0; } .cyp-bar .name { font-family: var(--mono); font-weight: 700; min-width: 90px; } .cyp-bar .track { flex: 1; height: 24px; background: var(--panel-2); border-radius: 6px; overflow: hidden; position: relative; } .cyp-bar .fill { height: 100%; border-radius: 6px; } .cyp-bar .pct { font-size: 12px; color: var(--ink-dim); min-width: 50px; text-align: right; font-family: var(--mono); } /* ============= DRUG TABLE ============= */ .drug-row { padding: 8px 0; border-bottom: 1px dashed var(--border); } .drug-row:last-child { border-bottom: none; } .drug-row .drug { font-weight: 600; color: var(--ink); } .drug-row .class { font-size: 12px; color: var(--ink-faint); margin-left: 6px; } .drug-row .note { font-size: 12px; color: var(--ink-dim); margin-top: 2px; } /* ============= SEARCH HIGHLIGHT ============= */ mark { background: var(--accent-3); color: #1a1300; padding: 0 2px; border-radius: 2px; } /* ============= UTIL ============= */ .text-dim { color: var(--ink-dim); } .text-faint { color: var(--ink-faint); } .text-good { color: var(--good); } .text-warn { color: var(--warn); } .text-bad { color: var(--bad); } .font-mono { font-family: var(--mono); } .center { text-align: center; } .row { display: flex; gap: 12px; flex-wrap: wrap; align-items: center; } /* ============= FOOTER ============= */ .footer { border-top: 1px solid var(--border); margin-top: 64px; padding: 32px 0; color: var(--ink-faint); font-size: 13px; } .footer .container { padding-top: 0; padding-bottom: 0; } /* ============= PRINT (for reference cards) ============= */ @media print { body { background: white; color: black; } .topbar, .footer, .pill-filter { display: none; } .card, .gene-card, .case-card { box-shadow: none; border: 1px solid #888; break-inside: avoid; page-break-inside: avoid; } .container { max-width: 100%; padding: 16px; } } /* ============= MERMAID OVERRIDE ============= */ .mermaid svg { max-width: 100%; } /* Animate flow through Mermaid edges */ .mermaid svg .edgePath path, .mermaid svg .flowchart-link { stroke-dasharray: 8 6; animation: flow-dash 1.6s linear infinite; } @keyframes flow-dash { to { stroke-dashoffset: -28; } } .mermaid svg .edgePath path.dashed { animation: flow-dash 2.4s linear infinite reverse; } .mermaid svg g.node rect, .mermaid svg g.node polygon, .mermaid svg g.node circle, .mermaid svg g.node ellipse { transition: filter .3s, transform .3s; transform-box: fill-box; transform-origin: center; } .mermaid svg g.node:hover rect, .mermaid svg g.node:hover circle, .mermaid svg g.node:hover polygon, .mermaid svg g.node:hover ellipse { filter: drop-shadow(0 0 12px var(--accent)); } /* ============= ANIMATED CUSTOM SVG ============= */ /* Flowing arrow path */ .flow-path { stroke-dasharray: 6 5; animation: flow-dash 1.4s linear infinite; } .flow-path.fast { animation-duration: .8s; } .flow-path.slow { animation-duration: 3s; } .flow-path.frozen { animation-play-state: paused; } /* Pulsing node */ .pulse-node { animation: node-pulse 2s ease-in-out infinite; transform-box: fill-box; transform-origin: center; } @keyframes node-pulse { 0%, 100% { transform: scale(1); opacity: 1; } 50% { transform: scale(1.06); opacity: .92; } } .pulse-node.urgent { animation-duration: .9s; } .pulse-node.danger { animation-duration: .7s; filter: drop-shadow(0 0 6px var(--bad)); } .pulse-node.calm { animation-duration: 4s; filter: drop-shadow(0 0 6px var(--good)); } /* Particle traveling along a path (uses SVG ) */ /* Loop counter + interactive controls */ .viz-frame { position: relative; background: var(--bg-2); border: 1px solid var(--border); border-radius: var(--radius); padding: 12px; overflow: hidden; } .viz-frame svg { display: block; width: 100%; height: auto; } .viz-controls { display: flex; gap: 10px; flex-wrap: wrap; padding: 12px 0 4px; align-items: center; } .viz-controls label { display: flex; align-items: center; gap: 8px; font-size: 13px; color: var(--ink-dim); cursor: pointer; background: var(--panel); border: 1px solid var(--border); padding: 6px 12px; border-radius: 999px; user-select: none; } .viz-controls label.active { background: var(--accent); color: #0b1020; border-color: var(--accent); font-weight: 600; } .viz-controls input[type="checkbox"] { accent-color: var(--accent); cursor: pointer; } .viz-controls .legend { font-size: 12px; color: var(--ink-faint); margin-left: auto; } .viz-counters { display: grid; grid-template-columns: repeat(auto-fit, minmax(140px,1fr)); gap: 8px; margin-top: 12px; } .viz-counter { background: var(--panel); border: 1px solid var(--border); padding: 10px 12px; border-radius: 8px; } .viz-counter .label { font-size: 11px; color: var(--ink-faint); text-transform: uppercase; letter-spacing: .06em; } .viz-counter .value { font-family: var(--mono); font-size: 22px; font-weight: 700; color: var(--bad); transition: color .3s; } .viz-counter .value.calm { color: var(--good); } /* Reduced motion */ @media (prefers-reduced-motion: reduce) { .mermaid svg .edgePath path, .mermaid svg .flowchart-link, .flow-path, .pulse-node { animation: none !important; } } /* ============= GLOSSARY TOOLTIPS ============= */ .gloss { border-bottom: 1px dotted var(--accent); cursor: help; text-decoration: none; } .glossary-tooltip { position: absolute; z-index: 100; max-width: 360px; background: var(--panel); color: var(--ink); border: 1px solid var(--accent); border-radius: 10px; padding: 12px 14px; font-size: 13px; line-height: 1.5; box-shadow: var(--shadow-2); opacity: 0; transform: translateY(-4px); transition: opacity .15s, transform .15s; pointer-events: auto; } .glossary-tooltip.visible { opacity: 1; transform: translateY(0); } .glossary-tooltip .t-term { font-family: var(--mono); font-size: 14px; color: var(--accent); margin-bottom: 4px; } .glossary-tooltip .t-exp { color: var(--ink-faint); font-weight: 400; font-size: 12px; margin-left: 6px; } .glossary-tooltip .t-def { color: var(--ink-dim); }